Sergio Garcia

Welcome to my personal website:

• You can reach me on Linkedin.
• My software is available on Github and GitLab.
• Below you can download my Ph.D. research papers, slides, and posters. You can also find my research on: Google Scholar, ORCID, and Research Gate.

Peer-reviewed papers:

1. Gene Co-expression Connectivity Predicts Gene Targets Underlying High Ionic Liquid Tolerance in Yarrowia lipolytica. Walker, C., Ryu, S., Garcia, S., Dooley, D., Mendoza, B., and Trinh, C. T. mSystems, 2022.
2. Computational Design and Analysis of Modular Cells for Large Libraries of Exchangeable Product Synthesis Modules. Garcia, S., and Trinh, C. T. Metabolic Engineering, 2021.
3. Development of a Genome-Scale Metabolic Model of Clostridium thermocellum and Its Applications for Integration of Multi-Omics Datasets and Computational Strain Design. Garcia, S., Thompson, R.A., Giannone, R. J., Dash, S., Maranas , C. D., and Trinh, C. T. Frontiers in Bioengineering and Biotechnology, 2020.
4. Harnessing Natural Modularity of Metabolism with Goal Attainment Optimization to Design a Modular Chassis Cell for Production of Diverse Chemicals. Garcia, S., and Trinh, C. T. ACS Synthetic Biology, 2020.
5. Understanding and Eliminating the Detrimental Effect of Thiamine Deficiency on the Oleaginous Yeast Yarrowia lipolytica. Walker, C., Ryu, S., Giannone, R.S., Garcia, S., and Trinh, C. T. Applied and Environmental Microbiology, 2019.
6. Single Mutation at a Highly Conserved Region of Chloramphenicol Acetyltransferase Enables Thermophilic Isobutyl Acetate Production Directly from Cellulose by Clostridium thermocellum. Seo, H., Lee, J., Garcia, S., and Trinh, C. T. Biotechnology for Biofuels, 2019.
7. Modular Design: Implementing Proven Engineering Principles in Biotechnology. Garcia, S., and Trinh, C. T. Biotechnology Advances, 2019.
8. Comparison of Multi-Objective Evolutionary Algorithms to Solve the Modular Cell Design Problem for Novel Biocatalysis. Garcia, S., and Trinh, C. T. Processes, 2019.
9. Multiobjective Strain Design: A Framework for Modular Cell Engineering. Garcia, S., and Trinh, C. T. Metabolic Engineering, 2019.
10. A Prototype for Modular Cell Engineering. Wilbanks, B., Layton D. S., Garcia, S., and Trinh, C. T. ACS Synthetic Biology, 2018.
11. Exploring Complex Cellular Phenotypes and Model-guided Strain Design with a Novel Genome-Scale Metabolic Model of Clostridium thermocellum DSM 1313 Implementing an Adjustable Cellulosome. Thompson, R. A., Dahal, S., Garcia, S., Nookaew, I., and Trinh, C. T. Biotechnology for Biofuels, 2016.

Download my references in BibTeX format.

Conference presentations:

1. Design of Modular Cells By Goal Attainment Optimization. Garcia, S., and Trinh, C. T. Talk presented at AIChE 2019, 2019. Orlando, FL.
2. Solving the Modular Cell Biocatalyst Design Problem with Multi-objective Evolutionary Algorithms. Garcia, S., and Trinh, C. T. Talk presented at Metabolic Pathway Analysis, 2019. Riga, Latvia.
3. Design of modular cells by goal attainment optimization. Garcia, S., and Trinh, C. T. Poster presented at Metabolic Pathway Analysis, 2019. Riga, Latvia.
4. Updated genome-scale metabolic model of Clostridium thermocellum with standard-conforming organization and improved prediction accuracy. Garcia, S., Thompson, R.A., Giannone, R., Dash, S., Maranas , C., and Trinh, C. T. Poster presented at Metabolic Pathway Analysis, 2019. Riga, Latvia.
5. Design, Techno-Economic Analysis, and Life Cycle Assesment of Consolidated Bioprocessing for Ester Production. Garcia, S., Hanes, R., Grundl, N., Biddy, M., and Trinh, C. T. Talk presented at Center for Bioenergy Innovation (CBI) Annual Science Meeting, 2019. Asheville, NC.
6. An Updated Genome-Scale Metabolic Model of Clostridium thermocellum that Simulates All Metabolic Fluxes under Diverse Conditions, Enabling New Insights in Data Analysis and Biocatalytic Strain Design. Garcia, S., Thompson, R.A., Giannone, R., Dash, S., Maranas , C., and Trinh, C. T. Poster presented at Center for Bioenergy Innovation (CBI) Annual Science Meeting, 2019. Asheville, NC.
7. Multiobjective strain design: A framework for modular cell engineering. Garcia, S., and Trinh, C. T. Poster presented at Constraint Based Reconstruction and Analysis (COBRA), 2018. Seattle, WA.
8. Linking overflow metabolism and growth cessation in Clostridium thermocellum. Thompson, R. A., Garcia, S., and Trinh, C. T. Poster presented at Metabolic Pathway Analysis, 2017. Bozeman, MT.
9. ModCell2: A multiobjective optimization platform for modular strain design. Garcia, S., and Trinh, C. T. Poster presented at Bioenergy Science Center (BESC) Retreat, 2017. Chattanooga, TN.
10. Metabolic network modeling of Clostridium thermocellum for systems biology and metabolic engineering. Thompson, R. A., Garcia, S., Dahal, S., Nookaew, I., Layton, D. S., Guss, A.M., Olson D. G., Lynd L. R., and Trinh, C. T. Poster presented at Clostridium XIV, International Conference on the Genetics, Physiology and synthetic Biology of Solvent- and Acid-forming Clostridia, 2016. Darthmouth, NH.
11. Analysis of flux distributions of Clostridium thermocellum mutants through physiological characterization and proteomics. Garcia, S., Thompson, R. A., Giannone, R., Hettich, R. L., and Trinh, C. T. Poster presented at Bioenergy Science Center (BESC) Retreat, 2016. Chattanooga, TN.

Doctoral dissertation:

• Garcia Manogil Fernandez, Sergio, "Design of Modular Cell Systems for Biocatalysis with Multi-Objective Optimization." PhD diss., University of Tennessee, 2020.
• Design of Modular Cell Systems for Biocatalysis with Multi-Objective Optimization. Garcia, S. Dissertation defense talk. Department of Chemical and Biomolecular Engineering, University of Tennessee Knoxville, March 2020. Knoville, TN.

March 16, 2023.